师资
个人简介：
苏明媛，金沙9001cc以诚为本医学院副教授、研究员，博士生导师。2012年和2015年先后在台湾大学获得生化科学硕士和博士学位，2016-2021年在美国加州大学伯克利分校的Dr. James H. Hurley实验室进行博士后研究，期间荣获AFTD Basic Science Postdoctoral Fellowship。2021年5月全职加入9001cc金沙医学院。近年来以第一/通讯作者在Nature，NSMB，Molecular cell，Nature Communications, Science Advances，Cell Reports 等国际学术期刊发表文章。Nature Communications, Cell Press, Cell Discovery, eLife 和Cell Reports 期刊审稿人。
教育背景：
2012-08至2015-08, 台湾大学, 生化科学, 博士
2010-08至2012-07, 台湾大学, 生化科学, 硕士
2005-08至2009-07, 台湾大学, 化学, 学士
工作经历：
2022-06至今 ， 金沙9001cc以诚为本医学院，副教授
2021-05至2022-05 ，金沙9001cc以诚为本医学院，助理教授
2016-08至2021-03, 美国加州大学伯克利分校/劳伦斯伯克利国家实验室, 博士后
2015-09至2016-07, 中央研究院生化科学研究所, 博士后
获奖情况及荣誉：
2019-2021 AFTD Basic Science Postdoctoral Fellowship
2016-2017 台湾中央研究院-博士后研究学者
2012-2014 澳门研究生资助发放技术委员会-研究生奖学金
2011,2013 台湾大学-研究所优秀侨生奖学金
2012 台湾大学生命科学院-院长奖
2005-2009 澳门教育暨青年局-大专奖助学金
研究领域：
课题组利用生物化学、细胞生物学、结构质谱学以及蛋白质结构解析技术研究：
1）溶酶体生物学相关的生物大分子结构和功能机制；
2）蛋白质稳态调控通路中的重要蛋白质结构解析、功能研究和转化应用
发表论文：
After 2021:
8. Su M-Y*,#, Teng F*, Wang S*, Mai X, Zeng H, Li J, Song X, Wang X and Stjepanovic G. Cryo-EM structures of amino acid sensors bound to the human GATOR2 complex. Cell Reports. 2025. https://doi.org/10.1016/j.celrep.2025.116088. (*equal contribution)
7. Zhang J*, Chen C*, Chen X*, Liao K, Li F, Song X, Liu C, Su M-Y, Sun H, Hou T, Tan C, Fang L#, Rao H#. Linker-free PROTACs efficiently induce the degradation of oncoproteins. Nat Commun. 2025 May 23;16(1):4794. (*equal contribution)
6. Wang Y, Liu M, Wang S, Mai X, Wang X, Teng F, Lyn T, Su M-Y#, Stjepanovic G#. Mechanism of D-type cyclin recognition by the AMBRA1 E3 ligase receptor. Sci Adv. 2025 May 23;11(21):eadu8708.
5. Zhang J, Chen X, Chen C, Li F, Song X, Liu C, Liao K, Su M-Y, Tan CSH, Fang L, Rao H. Distinct Amino Acid-Based PROTACs Target Oncogenic Kinases for Degradation in Non-Small Cell Lung Cancer (NSCLC). J Med Chem. 2024, 67(16):13666-13680.
4. Mai X, Wang Y, Wang X, Liu M, Teng F, Liu Z, Su M-Y#, Stjepanovic G#. Structural basis for membrane remodelling by the AP5:SPG11-SPG15 complex. Nature Structural & Molecular Biology. 2025. 10.1038/s41594-025-01500-0
3. Teng F*, Wang Y*, Liu M, Tian S, Stjepanovic G#, Su M-Y#. 2023. Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme. Structure 31, 1431-1440 e1435. (*equal contribution)
2. Liu M, Wang Y, Teng F, Wang X, Mai X, Su M-Y#, Stjepanovic G#. 2023. Structural basis for substrate recruitment by AMBRA1 E3 ligase receptor. Nat Commun. 2023 Nov 22;14(1):7631.
1. Su M-Y, Fromm SA, Remis J, Toso DB, Hurley JH. 2021. Structural basis for the ARF GAP activity and specificity of the C9orf72 complex. Nature Communications 12(1):3786.
Before 2021:
1. Su M-Y, Fromm SA, Zoncu R, Hurley JH. 2020. Structure of the C9orf72 Arf GAP complex haploinsufficient in ALS and FTD. Nature 585(7824):251-255.
2. Turco E*, Witt M*, Abert C*, Bock-Bierbaum T*, Su M-Y*, Trapannone R, Sztacho M, Danieli A, Shi X, Zaffagnini G, GamperA, Schuschnig M, Fracchiolla D, Bernklau D, Romanov J, Hartl M, Hurley JH, Daumke O, Martens S. 2019. FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates. Mol Cell 74:330-346.e11. (*equal contribution)
3. Turco E, Witt M, Abert C, Bock-Bierbaum T, Su M-Y, Trapannone R, Sztacho M, Danieli A, Shi X, Zaffagnini G, Gamper A, Schuschnig M, Fracchiolla D, Bernklau D, Romanov J, Hartl M, Hurley JH, Daumke O, Martens S. 2019. How RB1CC1/FIP200 claws its way to autophagic engulfment of SQSTM1/p62-ubiquitin condensates. Autophagy 15:1475–1477.
4. Su M-Y, Morris KL, Kim DJ, Fu Y, Lawrence R, Stjepanovic G, Zoncu R, Hurley JH. 2017. Hybrid Structure of the RagA/CRagulator mTORC1 Activation Complex. Mol Cell 68:835-846.e3.
5. Su M-Y, Som N, Wu C-Y, Su S-C, Kuo Y-T, Ke L-C, Ho M-R, Tzeng S-R, Teng C-H, Mengin-Lecreulx D, Reddy M, Chang C-I. 2017. Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc. Nat Commun 8:1516.
6. Lin C-C, Su S-C, Su M-Y, Liang P-H, Feng C-C, Wu S-H, Chang C-I. 2016. Structural Insights into the Allosteric Operation of the Lon AAA+ Protease. Structure 24:667–675.
7. Su M-Y, Peng W-H, Ho M-R, Su S-C, Chang Y-C, Chen G-C, Chang C-I. 2015. Structure of yeast Ape1 and its role in autophagic vesicle formation. Autophagy 11:1580–1593.
8. Chao S-W, Su M-Y, Chiou L-C, Chen L-C, Chang C-I, Huang W-J. 2015. Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene Kinase Pim-1. J Nat Prod 78:1969–1976.
9. Su M-Y, Chang C-I, Chang C-F. 2013. 1H, 13C and 15N resonance assignments of the pyrin domain from human PYNOD. Biomol NMR Assign 7:141–143.
10. Su M-Y, Kuo C-I, Chang C-F, Chang C-I. 2013. Three-dimensional structure of human NLRP10/PYNOD pyrin domain reveals a homotypic interaction site distinct from its mouse homologue. PLoS ONE 8:e67843.